EFFECT OF ANTIVENOM OF Echis carinatus SNAKE ON HEMATOLOGICAL PARAMETERS AND LIVER ENZYMES OF MALE AND FEMALE RATS

Sami J. Al-Maliki, Khalid G. Al-Fartosi* and Baida R. Ali

ABSTRACT

The present study aimed to investigate the effect antivenom of Echis carinatus on hematological parameters and liver enzymes of rats. Adult male and female rats divided into three groups for each sex (6 for each group), the first group injected (i.p.) with normal saline (0.9%Nacl) as a control group, the second group injected (i.p.) with(0.25ml/kg/day) of antivenom for two times, and the third group injected with (0.5ml/kg/day) of antivenom for two times. Animals killed within 24 hours. Results indicated a significant increase (P≤0.05) in redblood cell count (RBC), meancorpuscular hemoglobin (MCH), mean concentration corpuscular hemoglobin (MCHC) packed cell volume (PCV), mean corpuscular volume (MCV), total (WBC), lymphocytes, monocytes and granulocytes in male and female rats of second andthird groups compared with the control group. Also, it showed a significant increase(P≤0.05) in the number of platelets in third group of male and female rats compared with the first andsecond groups.Also, it showed a significant increase(P≤0.05) in the liver enzymes ALT, AST and ALP in second and third groups of male rats compared with the control group. There was significant increase(P≤0.05) in the liver enzymes ALT, AST in third group compared with the second andcontrolgroup, while showed ALPsignificant increase(P≤0.05) in third compare with the second and control groups.

Keywords: Antivenom, blood parameters, liver enzymes, rats.