EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

INVESTIGATION OF ANTIOXIDANT POTENTIAL OF AN ETHANOLIC EXTRACT OF WHOLE PLANT OF LEONOTIS NEPETIFOLIA (L). R.BR.

K. Vasuki*, R. Senthamarai and P.Sudhakar

ABSTRACT

In this study antioxidant activity was performed by hydroxyl radicals, DPPH and nitric oxide radical scavenging method for an ethanolic extract of whole plant of Leonotis nepetifolia (L). R.Br. An extract was used at different concentrations like 1.25, 2.5, 5.0, 10.0, 20.0 μg/ml and radical scavenging activity was determined in terms of percentage inhibition and IC50 values were calculated. The study proved that an ethanolic extract of Leonotis nepetifolia found to have highest antioxidant activity against nitric oxide radical (% inhibition = 77.07 ± 1.77; IC50 = 2.03 μg/ml) and moderate activity against DPPH radicals (% inhibition = 64.47 ± 1.42; IC50 = 3.07 μg/ml) and minimum activity against hydroxyl radicals (% inhibition = 62.96 ± 1.78; IC50 = 7.55 μg/ml) at concentration of 20 μg/ml. The strongest antioxidant activity of an ethanolic extract may be due to the presence of flavonoids. The further study has to be focused on isolation and characterization of functional molecules of the extract and their individual activity.

Keywords: Leonotis nepetifolia (L). R.Br., in vitro antioxidant activity, free radicals.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)