EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

STUDY ON ZINGIBER CHRYSANTHUM ROSC. RHIZOME ESSENTIAL OIL FOR ITS ANTHELMINTIC ANTI-DIARRHOEAL AND ANTIBACTERIAL ACTIVITIES.

Manisha Arora, Mahesh Chandra, H. Tewari , Jugendra Pal , A.K.Pant,
A.H. Ahmad and Om Prakash*

ABSTRACT

Zingiber chrysanthum Rosc.(Zingiberaceae) rhizome essential oil (ZCREO) was studied for its effect on isometric contractions of Ascaridia galli. The amplitude and frequency of spontaneous contractions of A. galli were recorded on physiograph through force transducer. The oil exhibited significant effect and percent response inhibition on the contractility of A galli in terms of amplitude frequency and base line tension in dose dependent manner with an IC50 value of 6.25 ± 0.23 mg/ml. Antidarrhoeal activity of ZCREO was also evaluated on castor oil-induced diarrhea in mice. The oil showed dose dependent increase in time of onset of first wet faeces and reduces total number of faeces and number of wet faeces. This indicates that ZCREO reduces peristaltic movements of gastro-intestinal tract, and acts as potent anti-diarrheal drug. The oil exhibited moderate antibacterial activity against pathogenic bacteria viz; E.coli, S.enterica enterica, P.multocida and S. aureus with MIC values ranging 3.90-31.25 μl/ml.

Keywords: Ziniber chrysanthum, anthelmintic, castor oil, antidarrhoeal activity, antibacterial activity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)