SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF CO(II), NI(II), CU(II) AND ZN(II) COMPLEXES OF SCHIFF BASE DERIVED FROM ISATIN MONOHYDRAZONE AND FURFURALDEHYDE

C. Agatha Christiea, C. Shijub and T. F. Abbs Fen Rejia*

ABSTRACT

A Schiff base, obtained by the condensation of isatin monohydrazone with furfuraldehyde (L1) and its Co(II), Ni(II), Cu(II) and Zn(II) complexes as well as its mixed ligand complexes with 1,10-phenonthroline were synthesized. The ligands and their complexes were characterized by elemental analysis, molar conductance, FAB-mass, 1HNMR, 13CNMR, FT-IR, electronic spectra, magnetic moment, TGA and powder XRD studies. The analytical data show that the metal to ligand ratio is 1:1. The result showed that the Schiff base ligands act as a biidentate donor. The thermogravimetric analysis indicates the presence of lattice water molecules in the complexes. All the compounds have been tested in vitro against various pathogenic bacteria and fungi. DNA cleavage activity of the ligand and its complexes were assayed on Escherichia coli DNA using gel electrophoresis in the presence of H2O2. The anticancer activities of some selected complexes have also been studied towards human cervical cancer cell line (HeLa). Copper complexs was found to be most potent biologically active compound.

Keywords: Schiff base, Metal complexes, Isatin, Furfuraldehyde, Antimicrobial, DNA cleavage.