EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

PREPARATION & EVALUATION OF VALSARTAN NANOPARTICLES

Chirravuri S. Phani Kumar*, V. Jyothi Krishna Reddy, V. Srinivasa Rao, K. Suresh Kumar, N. V. N. Koteswara Rao, Surisetti Roja

ABSTRACT

Valsartan belongs to BCS class II drugs (low aqueous solubility and high permeability), hence the oral absorption (20-30%) of the drug is dissolution rate limited. Improvement of dissolution velocity of Valsartan is desired so as to improve its bioavailability. The objective of the present research is to improve the dissolution rate of the drug adopting the concept of nanonization. Simple mixing and probe sonication were employed to prepare nanocrystals using 3 polymers namely Polyvinyl pyrrolidone (PVP K30), polyvinyl alcohol (PVA), polyethylene glycol (PEG 400) as stabilizers. Nanoparticles were characterized by FT-IR, SEM, assay, dissolution & micromeritics studies. Finally simple mixing was considered as best method compared to probe sonication method, in which PEG 400 is the best polymer as stabilizer to enhance the dissolution of Valsartan at 1 : 0.5 (Valsartan: PEG 400) concentration ratio.

Keywords: Valsartan, nanoparticles, simple mixing, probe sonication.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)