EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

FREE RADICAL SCAVENGING PROPERTY OF ?-AESCIN AND TRANS-CHALCONE: IN VITRO STUDY

Harsimran Singh*, Shabir Sidhu and MU Khan

ABSTRACT

The aim of the present study was to investigate the antioxidant activity of β-aescin and trans-Chalcone by using in-vitro DPPH assay. Ascorbic acid was used as standard antioxidant compound. β-aescin is active phytoconstituent found in the extract of horse chestnut (Aesculus hippocastanum L.) seed. trans-Chalcone is open chain flavonoid biosynthesized in plant, Piper methysticum and synthesized in laboratory by Claisen-Schmidt condensation. The concentration range of 10, 20, 40, 60, 80 and 100 μg/mL of both the drug solutions was used. Our data showed that β-aescin and trans-Chalcone exhibited antioxidant activity in a concentration dependent manner, indicated by % inhibition and IC50 value. The IC50 value of β-aescin, trans-Chalcone and ascorbic acid (standard drug) were found to be 1.54, 1.45 and 1.47 respectively. Moreover, on the basis of IC50 values, trans-Chalcone exhibited more potent antioxidant activity when compared with standard compound and β-aescin. The range of antioxidant behavior is trans-Chalcone > ascorbic acid > β-aescin.

Keywords: trans-Chalcone; ?-aescin; Oxidative stress.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)