PLACENTAL CHORANGIOSIS: THE ASSOCIATION WITH NEONATAL MORBIDITY AND MORTALITY

*Amulyajit Kaur, Dr. Kanwaljeet Singh Hura, Akanxa Bhatti, Dr. Neeraj Kaur

ABSTRACT

Aim: Chorangiosis and related placental vascular lesions (the entire spectrum being referred to as chorangiomatosis) have not been extensively studied and chorangiosis especially has been consistently underreported. This study aims to highlight the association of these vascular lesions with neonatal mortality and morbidity. Material and methods: Three hundred and forty seven consecutive placentas from abnormal maternal, fetal or neonatal outcomes received in a tertiary care hospital were studied with special emphasis on chorangiomatous lesions as per defined criteria. Association with neonatal death, prematurity, pregnancy induced hypertension, placental ischemia and hypoxia was studied. Results: Among the 347 placentas received in a tertiary care hospital, 16 had evidence of chorangiomatosis. Overall incidence of chorangiomatosis in these cases was 4.6% and 43.7% of these cases were associated with a fatal outcome. This study shows a strong positive association of chorangiomatous lesions with neonatal death, prematurity, pregnancy induced hypertension, placental ischemia and hypoxia. This underlines the significance of chorangiosis and related placental vascular lesions as signs of neonatal morbidity and mortality. The interplay of maternal, fetal and placental factors may combine to produce this pathologically distinct entity of potential clinical significance.

Keywords: Placental chorangiomatosis, neonatal mortality, morbidity.