EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

HORMONAL INFLUENCE ON PHOSPHOLIPASE D AND TRIGLYCERIDE LEVELS IN THE LIVER; INTERACTION WITH PHOSPHATIDIC ACID PHOSPHOHYDROLASE ENZYME

Manoj G Tyagi*, Aniket Kumar, Anand R and S Vilvan

ABSTRACT

Several studies suggest that insulin resistance is associated with alterations in the lipid levels particularly with the triglycerides. This study was conducted to ascertain the effects of pancreatic hormone insulin and adrenergic neurotransmitter norepinephrine (NE) on the phospholipase D (PLD) enzyme activity and triglycerides levels in goat liver. Goat Liver homogenates were subjected to treatment with insulin and norepinephrine and the PLD activity was ascertained. Pretreatment with phosphatidic acid phosphohydrolase inhibitor, Propranolol potentiated the effects of insulin and NE on PLD by 16.28% and 21.32 % respectively. On the other hand PLD inhibitor 2, 3 Bisphosphoglycerate (2,3 BPG) attenuated the effects of insulin and NE on PLD activity. A Similar trend was seen with the 2,3 BPG treatment on triglyceride levels estimated in the goat liver. It can be suggested from our results that phospholipase D enzyme mediated pathway may be partially responsible for the synthesis and regulation of triglyceride levels in the goat liver.

Keywords: Phospholipase D, Triglycerides, Insulin, Norepinephrine, Liver, Propranolol.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)