EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

AJIMOMOTO (MSG): A FIFTH TATSE OR A BIO BOMB

Vivek Sharma* and Rahul Deshmukh

ABSTRACT

This review assesses many of the health implications associated with monosodium glutamate (MSG) in humans and animals. MSG is the sodium salt of glutamic acid and has been used all over the world for its flavor enhancing properties. The prevalence of this salt as a food additive in Asian cuisine and other diets makes MSG a relevant aspect of the human diet worldwide. It increases the appetite by stimulating the appetite centre but nowadays it has been debated for its safety and harmful effects as it affect almost every major organ in the body. The studies on experimental animals have confirmed toxic effect of MSG in different organs, mainly manifested by increased oxidative stress, cytotoxicity, immunosupresion, reproductive toxicity(males and females), obesity, asthma, autism and numerous other ailments. For thirty years, scientists and researchers have used MSG in their experiments to purposely create obese and pre-diabetic test subjects, trigger epileptic seizures, create ischemic strokes, produce oxidative stress, neurobehavioral abnormalities and destroy cell tissues in vivo and in vitro. Additionally, MSG is known to produce impairment in memory retension, damage in the hypothalamic neurons, alterations in mitochondrial lipid peroxidation and antioxidant status in different regions of brain. Beside this MSG induces a shift in the carbohydrate metabolism towards lipogenesis leading to hyperlipidemia and hyperglycemia. Furthermore, MSG induced oxidative stress in erythrocytes, liver, kidney, heart and brain of experimental animals has also been documented. Debate over the healthiness of MSG and its associated health problems has led to a negative public opinion of the additive. Present review make it safe to conclude that MSG has the potential to create several health hazards and thus advocates strict guidelines and mass awareness regarding its use.

Keywords: Ajinomoto, cytotoxicity, cognitive deficits, mono sodiium glutamae, obesity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)