PHARMACOLOGICAL ASSESSMENT OF ARJUNA GHRITA FORMULATIONS FOR MOOTRASANGRAHNIYA (ANTI-DIURETIC) ACTIVITY IN RATS

Hetal Aghera*, Vishva Savaliya, Maulik Ghetia, Mukesh Nariya, Vinay Shukla and
Pradeepkumar Prajapati

ABSTRACT

The formulations of Terminalia arjuna Roxb. Arn. & Wt. bark are highly recommended for cardiac patients. In classics Arjuna is also reported as mutrasangrahniya (Anti-diuretic). However, other properties and uses of Arjuna are not well-known. Therefore, the present study is aimed to assess anti-diuretic activity of Arjuna ghrita on acute and long-term administration in rats to support the traditional claim made on Arjuna. In acute study, the test formulations were administered once while in chronic study test formulations were administered for 7 consecutive days. Furesemide (10 mg/kg/day) was used as reference standard drug. Total urine volume at 6 and 24 hrs, pH, specific gravity and electrolytes excretions were evaluated in acute and chronic phase of study. The results revealed that there was decease in urine volume, pH, and specific gravity and significantly diminish electrolyte excretions in Arjuna ghrita treatment, which is totally reversal to furesemide, a standard diuretic drug denoted that Arjuna ghrita (4.3g/kg, po) was act as anti-diuretic or urinary astringent in albino rats and may be useful in the clinical conditions of nocturia.

Keywords: Terminalia arjuna Roxb. Arn. & Wt. Arjuna ghrita, Urinary astringent, Furesemide, Anti-Diuretic activity.