EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

POORLY SOLUBLE DRUGS- A CHALLENGE IN DRUG DELIVERY SYSTEM

Padmini H. Sharma*, Shweta N. Kalasare, Hardik Damania

ABSTRACT

The therapeutic effectiveness of a drug depends upon the bioavailability and solubility. The process of solubilisation involves the breaking of inter-ionic or inter-molecular bonds in the solute, the separation of the molecules of the solvent to provide space in the solvent, interaction between the solvent and the solute. The various factors affecting solubility are particle size, temperature, pressure, nature of the solute and the solvent, molecular size, polarity, etc. It is estimated that about 40% of compounds being developed by pharmaceutical industry are poorly water soluble which serves serious challenge to the successful development of new drugs. A limiting factor to this is the inadequate dissolution rates. Thus, increasing the dissolution rate of poorly water soluble active pharmaceutical ingredients has become a major challenge and transfers them into highly bioavailable drug delivery systems by distinct measures such as chemical transformation, biopharmaceutical measures and physiological measures. Multiple technologies are available for the successful formulation of poorly soluble drugs such as controlled precipitation, ultra-rapid freezing, hydrotropic solubilisation, complexation, solid dispersion, salt formation, use of co-solvents, solubilzing agents, co-crystallization, etc. Overall, discoveries of new technologies will be useful for drugs with problems of poor solubility and bioavailability, which would allow future drugs and new entities to reach market successfully and thereby, serve mankind in a better way.

Keywords: Solubilisation, Bioavailability, Solubility, Pharmaceutical Industry.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)