SYNTHESIS AND STRUCTURAL DETERMINATION OF NOVEL CURCUMIN OXIME GOLD(III)COMPLEX:POTENTIAL CHEMOPREVENTIVE DRUG

Kalyani P., Subrahmanyam Naidu P.V.* and Prakash MMS Kinthada*

ABSTRACT

Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Cancer is a class of diseases characterized by out-of-control cell growth. Cancer harms the body when damaged cells divide into uncontrollably to form lumps or masses of tissue called tumors. Tumors that stay in one spot and demonstrate limited growth are generally considered to be benign. Cancerous cell manages to move throughout the body using the blood systems, destroying healthy tissue in a process called invasion. Cur cumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers. The anticancer potential of cur cumin is severely affected by its limited systemic and target tissue bioavailability and rapid metabolism. Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic preparations in Indian System of medicine. In the present research work, we provide a summarized synthesis and structural determination of Curcumin Oxime derivative of Gold(III)complex. The use of these analogs for prevention of cancer tumor progression and treatments of human malignancies.

Keywords: Curcumin, Curcumin Oxime, chemoprevention, therapy, human malignancy.