FORMULATION AND EVALUATION OF PH TRIGGERED INSITU GELLING SYSTEM CONTAINING LEVOFLOXACIN

Harshitha V. Y.*, Somashekar C. N. and Navaneethan S.

ABSTRACT

Topical administration of a drug in the conjunctival cul-de-sac is the treatment of choice for diseases of the anterior segment of the eye. The Development of ophthalmic drug delivery systems has always been challenging because of the drawbacks of this route, like non-productive absorption, drainage, induced lacrimation, tear turnover, and impermeability of drugs to the cornea. New approaches have been investigated to deliver drugs to the eye utilizing polymeric delivery of ophthalmic drugs to the pre-and intraocular tissues. They have attempted to increase the bioavailability and the duration of therapeutic action of ocular drugs. Specific new approaches to increase the ocular bioavailability and duration of the drug action and reduce the undesirable side effects are using drug carriers that regulate pre-corneal drug loss and improve the corneal contact time. Many of these systems prolong ocular bioavailability but do not control drug penetration through the cornea. Consequently, the drug concentration at the site of action might remain inadequate. Therefore, developing a safer, more productive, and more acceptable ocular therapeutic system is necessary. they can improve the ocular bioavailability of the drugs by prolonging their residence time in the cul-de-sac and increasing their corneal permeability. Various new dosage forms include in-situ gel, collagen shield, etc. Conventional ocular drug delivery systems like eye drops, ointments, and suspensions have varied disadvantages of lachrymation, and blurred vision. The developed formulation was therapeutically efficacious, stable, non-bother and provided sustained unleash of the drug. This review tries to debate the newer Developments and techniques for this drug delivery together with physiological factors, physicochemical factors and formulation factors to be thought about within the Development of an unchanged drug delivery system.

Keywords: Opthalmic Fomulations, pH Triggering systems, Gellan Gum, etc.