IGY ANTIBODIES FROM EGGS DERIVED FROM DIFFERENT BIRD SPECIES AGAINST H5N1, H9N2 AND NDV

Aya Saed, Emad Elgendy and Madiha Salah Ibrahim*

ABSTRACT

IgY is the major antibody produced by the B cells of domestic birds. It is functionally comparable to mammalian IgG but differs in their structure. Because of its production in large amount and easy way, IgY becomes desirable to be used in both therapeutic and diagnostic approachs in chickens and other bird species. Here, we tested the neutralization ability and efficiency of IgY collected from different bird species, chicken, quail and duck, against avian influenza virus H5N1 and H9N2 as well as Newcastle disease virus. The results showed that IgY collected from different bird species were in high titer and can neutralize the viruses efficiently, exhibiting the ability of using the IgY antibodies as a prophylactic therapy against different viral diseases.

Keywords: H5N1, H9N2, NDV, IgY, Heamaglutination inhibition, ELIZA.