A CASE REPORT ON CLOZAPINE INDUCED SIALORRHEA

Raveena Rajesh*, Jayalakshmi J. and Roshiny Thankam James

ABSTRACT

Hypersalivation, or ptyalism also known as sialorrhea or hypersialosis is the excessive production of saliva. It has also been defined as increased amount of saliva in the mouth, which may also be caused by decreased clearance of saliva. Hypersalivation can contribute to drooling if there is an inability to keep the mouth closed or difficulty in swallowing (dysphagia) the excess saliva, which can lead to excessive spitting. Hypersalivation also often precedes emesis (vomiting), where it accompanies nausea (a feeling of needing to vomit). Clozapine is an antipsychotic medicine. It works by changing the actions of chemicals in the brain. Clozapine is also used to reduce the risk of suicidal behavior in people with schizophrenia or similar disorders. Common adverse effects include drowsiness, constipation, hypersalivation (increased saliva production), tachycardia, low blood pressure, blurred vision, weight gain, and dizziness.

Keywords: Clozapine, Drooling, Hypersalivation, Antipsychotics, Sialorrhea.