AN OVERVIEW ON REMDESIVIR FOR THE TREATMENT OF COVID-19

Kavitha M.*, Akshara S. P., Sajitha P. and Pavithra S.

ABSTRACT

The coronavirus disease 2019(covid-19) pandemic,has caused considerable challenges to the National healthcare systems in this world. Coronaviruses use an RdRp enzyme to carry out replication and transcription of their RNA genome. Discovered in the 1960s, they had been at the beginning idea to be only responsible for moderate disease, with lines such as HCoV 229E and HCoV OC43 accountable for the common cold. That modified in 2003 with the SARS pandemic and in 2012 with the outbreak of MERS, each zoonotic infections that resulted in mortality prices increased than 10% and 35%, respectively. The common symptoms include fever, cough, dyspnea, chest pain and pneumonia. Remedesivir is a phosphoramide prodrug is only approved drug for the treatment of covid-19 patients. The aim of the study to examines the structure, First approval, journey of remdesivir, registered pattern of remdesivir, mechanism of action, dosing, adverse effect, pharmacokinetics and pharmacodynamics, drug interactions of remdesivir.

Keywords: COVID-19, Corono virus, Ebola virus, Remdesivir structure, pharmacokinetics, Pharmacodynamics, Drug interaction, adverse effect.