EFFICACY OF ITRACONAZOLE VERSUS FLUCONAZOLE IN VAGINAL CANDIDIASIS

*Priyanka G. and Jyoti S.

ABSTRACT

Objective: To compare the efficacy of itraconazole 200mg twice and fluconazole 150mg single dose for one day in the treatment of acute VVC (vulvovaginal candidiasis(VVC)). Methods: The study was carried out at the sub himalyan peripheral institutes Ch Bhawarna and RH Bilaspur, from September 2021 to February 2022 and comprised 50 women with mycological and clinical diagnosis of vaginal candidiasis. Based on history, clinical examination and relevant investigations the diagnosis was based. The women were divided into 2 equal groups. After the initial assessment, Group 1 was treated with capsule fluconazole 150mg stat whereas Group 2 with capsule itraconazole 200mg twice for one day again. They were assessed clinically for cure and the relapse on day seven and twenty-one respectively. In the proforma all findings were recorded. Data was analysed using SPSS 12. Results: The overall clinical evaluation showed 50% with fluconazole and 70% cure rate with itraconazole. In Group-1, (23.00%) and in Group-2 (26.00%) showed some improvement, while (06.66%) in Group 1, and (23%) in Group 2 failed to respond to the treatment. Relapse was observed in (28.5%) and (53%) of the cured cases in Group 1 and Group 2 respectively. Conclusion: Compared to fluconazole; Itraconazole was found to be more effective in the treatment of vulvovaginal candidiasis (VVC) with high cure rate and low relapse rate.

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