EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

EVALUATION OF ANTI-DIABETIC ACTIVITY OF SELECTED PLANT IN DRUG INDUCED DIABETIC RATS

Ajaz Ahmed Bhatt, Dileep Kumar, *Ayush Garg, Jayesh Dwivedi, Ravisha Suthar and Urja Kumari

ABSTRACT

The medicinal plant Murrayakoenigiishown to have a widevariety of pharmacological activities (hypoglycemic and hypolipidemic).Objective of this study is the present study was designed to evaluate of Antidiabetic activity of Murrayakoenigiiin drug induceddiabetic rats.Oral administration of ethanolextracts of Murraya leaf (300 and 500mg/kg body weight) for 30 days resulted in significant decrease of bloodglucose from 76.96±3.47 to 62.35 ± 2.07 and decrease in the activities of enzymes of liver. Diabetic rats treated with murraya(55 ml/kg/bw) showed an improvement in the spleenhistology and treated with Murraya(50 ml/kg/bw) shows a result similar to that of non- diabetic control. Theresults showed not only significant anti-hyperglycaemic effect of Murraya extracts in experimental model ofdiabetes mellitus but also indicated a dose dependant activity of the extracts.

Keywords: Diabetes, Hypoglycaemic, MurrayaKoenigii.


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SJIF Impact Factor: 7.065

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