EVALUATION OF NEPHROPROTECTIVE ACTIVITY OF CADABA FRUTICOSA LEAVES BY GENTAMICIN INDUCE NEPHROTOXICITY ON EXPERIMENTAL ANIMALS

Firoz Khan*, Dr. Nasiruddin Ahmad Farooqui, Praveen Kumar and Jiyaul Hak

ABSTRACT

The protective effect of Cadaba fruticosa leaves extract against Gentamicin-induced nephron toxicity into Wistar albino rats was examined through several biochemical limitations. Renal damage produced through Gentamicin was well revealed by a substantial improve in renal parameters like volume of urine, body mass, serum creatinine, serum bun, creatinine clearance, MDA Level, SOD, CAT, glutathione proxidise, reduce glutathione, serum uric acid, blood urea nitrogen, and serum urea. Oral administration of Kadaba furticosa levees ethanolic extract (150 mg/kg and 300 mg/kg, p.o) along with Gentamicin restored these altered parameters to normal levels, indicating the protective effect of Kadaba furticosa on Gentamicin-induced renal injury. More extensive research is needed on its potential use in clinical practice.

Keywords: MDA Level, SOD, CAT, glutathione proxidise, reduce glutathione.