EVALUATION OF ANTIDIABETIC ACTIVITY OF COCCINIA INDIA LEAVES EXTRACT ON EXPERIMENTAL ANIMALS

Mohammad abu Mobin Akhtar*, Dr. Nasiruddin Ahmad Farooqui, Dr. Shamim Ahmad Mr. Jiyaul Hak

ABSTRACT

Safety profile is essential for the drugs obtained from the plant origin. The level of toxicity can be evaluated by toxicological studies. From the results it was concluded that the ethanolic leaves extract of coccinia indica showed significant anti-diabetic activity in a dose dependent manner compared to the standard drug glibenclamide. The result also showed significant decrease in the liver Alkaline phosphatase(ALP), Aspartate amino transferase (AST), Alanine amino transferase (ALT), serum urea level, cholesterol, triglycerides, VLDL and LDL was in STZ induced diabetic animals when compared to control group. It is concluded that ethanolic leaves extract of coccinia indica showed significant effect in STZ induced diabetic rats. Further studies are necessary to examine the underlying mechanism of hypoglycemic effect and to isolate the active compound (s) responsible for anti-diabetic activities.

Keywords: cholesterol, triglycerides, VLDL and LDL.