FORMULATION AND EVALUATION OF POLYHERBAL LOZENGES FOR THE TREATMENT OF ORAL ULCERS

Bariki Rajasekhar*, C. Supriya, K. Guru Lakshmi, M. Shireesha, M. Mujeeb Ur Rehaman, P. Prasanna Kumar and Y. Saroja

ABSTRACT

Herbal Medicines are still the mainstay of about 75-80% of the world’s population, mainly in developing countries. They are found mainly in tropical and subtropical regions of the India for primary health care because of better compatibility with human body, cultural acceptability and lesser side effects. Herbal Formulations are derived from Herbal plant extracts and these are being increasingly utilized to treat a wide variety of diseases. The main objectives of present investigation were to formulate and evaluate polyherbal lozenges for the treatment of oral ulcers by using ethnolic extracts of guava, liquorice, neem, tulasi and different concentration of Hydroxypropyl Methylcellulose, Methylcellulose polymers. The prepared polyherbal lozenges formulations were characterized for various parameters like hardness, thickness, weight variation, friability and dissolution by standard pharmacopeia methods. However, that among all formulations, HF3 Polyherbal Lozenges was proved most promising formulation as it showed that 93.74 % drug release with in 30 minutes. The diameter, thickness and hardness of lozenges were found to be 16.11±0.08mm, 6.552±0.02mm and 5.5 ± 0.3 (kg/cm2) respectively. The percentage of weight variation was found to be 3000.6 ± 2.65 mg. The friability of lozenges was found to be 0.92 ± 0.02 (%). Among all the Formulations HF3 with HPMC Polymer Polyherbal Lozenges showed best results because all the Evaluation parameters showed satisfactory results.

Keywords: Guava, Liquorice Neem, Tulasi, Polyherbal formulation, Lozenges, Ulcer treatment.