FORMULATION AND DESIGN OPTIMIZATION OF NANO ETHOSOMAL GEL FOR DELIVERY OF RASAGILINE MESYLATE: IMPROVEMENT IN BRAIN LOCALIZATION AND BIOAVAILABILITY

Navaneethan S.*, Somashekhar C.N. and Harshitha V.Y.

ABSTRACT

To Improve the developed of nano ethosomes containing Rasagiline mesylate for effective treatment of Parkinson’s disease. Nano ethosomes were prepared by the cold method. D- for applied optimal design for formulation optimization. Ethanol, propylene glycol, and phospholipids were selected as independent variables, while encapsulation efficiency (EE) of the nano ethosomes was a dependent variable. In the optimum formulation of RM ethosomes, in which ethanol (30.0%), propylene glycol (20.0%), and phospholipids (2.0%) have a higher EE of 83.14% with spherical bilayered structure revealed from SEM analysis, the average particle size range of 153.7 nm and zeta potential values obtained as -31.4mV. Further, the nano ethosomes formulations showed controlled release of drug for 12hours. After fitting in-vitro drug release data into various kinetic models, to found the release to follow the first-order model. These results confirmed that nano ethosomes containing Rasagiline mesylate have the potential for the treatment of Parkinson’s disease.

Keywords: Nano ethosomes, Parkinson’s disease, Rasagiline mesylate, D- optimal design, Entrapment efficiency.