HISTOMORPHOLOGICAL EFFECT OF NANDROLONE DECANOATE ON THE HEPATORENAL TISSUES OF ADULT WISTAR RAT EXPOSED PHYSICAL ACTIVITY

Ebeye O. A., *Ekundina V.O. and osahon R.I.

ABSTRACT

Nandrolone Decanoate is a type of Anabolic Androgenic Steroid is used by athletes and non-athletes to increase their performance, body weight and also to cure ailment. This study is aimed at investigating the intraperitoneal effect of Nandrolone Decanoate on the liver and kidney with an administration which lasted for 28-days on ten (10) adult wistar rats male and female respectively. The models where divided into three groups. Group A (Control) received distilled water and rat feed Group B (Sedentary) received Nandrolone decanoate and where not subjected to physical exercise while Group C (Exercise) nandrolone Decanoate was administered to them and where subjected to physical exercise of swimming in water till they experience drowning. The rats where sacrificed at the end of the 28 day. The liver and kidney were removed and processed for histopathological analysis. The results from the study showed hepatic tissue with periportal infiltration of the polymorphonuclear cells for sedentary models and congestion of vascular channels, fat deposit and binucleated hepatocyte for the exercise model, While the renal tissue of the sedentary models revealed glomerulosclerosis, glomerular edema with tubular degeneration and the renal tissue from the exercised models revealed the renal tissue that are essentially normal. The study showed that Nandrolone Decanoate induced hepato-renal toxicity, consumers should be cautioned.

Keywords: Nandrolone Decanoate, binucleated hepatocyte, periportal infiltration.