EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF METHOTREXATE IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORM

Madhumita Roy*, Mukesh Mohite and Sandesh Shah

ABSTRACT

A new RP-HPLC method was developed and validated for determination of Methotrexate in bulk and tablet dosage form. The estimation was carried out on Enable C18 (250 mm ×4.6 mm, 5 μm) column using Distilled water: Acetonitrile in the ratio of 80:20 (v/v) at pH 3 with Formic acid as mobile phase. The flow rate was 1.0 ml/min and the effluent was monitored by UV detector at 211 nm. The retention time was 3.28 min and linearity was observed in the concentration range of 8-60μg/ml. The percentage recovery was in good agreement with the labelled amount in the pharmaceutical formulations and the method was simple, precise and accurate for the determination of Methotrexate in bulk and pharmaceutical formulations.

Keywords: Methotrexate, HPLC, Validation.


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SJIF Impact Factor: 7.065

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