ASSOCIATION BETWEEN SERUM 25-HYDROXYVITAMIN D CONCENTRATIONS AND METABOLIC SYNDROME IN THE MIDDLE-AGED INDIVIDUAL

Dr. Afsana Akhter*, Dr. Nowrose Jahan, Dr. Kohinoor Akter, Dr. Sumi Dey, Dr. Purabi Barman and Dr. Shahanaz Akter

ABSTRACT

Background: Metabolic syndrome (MetS) has become one of the most important threats to human health worldwide in both developed and developing countries. Vitamin D deficiency has been identified as a public health issue and it could be a risk factor for MetS. Epidemiological studies show that serum concentrations of vitamin D are inversely associated with MetS. Objective: This study aims to find out the association between serum 25-hydroxyvitamin D concentrations and metabolic syndrome in the middle-aged individual. Methods: This cross-sectional analytical study was carried out to find out the association between serum 25-hydroxy vitamin D concentrations and metabolic syndrome in the middle-aged individual. For this study, 90 subjects were recruited after fulfilling the inclusion and exclusion criteria. Study subjects were divided into two groups: 45 subjects with MetS and 45 subjects without MetS. Results: Baseline characteristics showed that BMI and WC were significantly higher in subjects with MetS than the subjects without MetS (27.89±4.13 vs. 23.53±3.47; p<0.001 and 94.09±8.76 vs. 87.78±8.68; p value: 0.001) respectively. Mean (±SD) of serum vitamin D was significantly lower in MetS subjects as compared to subjects without MetS (26.50±5.94 vs. 30.51±5.80; p value: 0.002). This study showed FPG was significantly higher in subjects with MetS than subjects without MetS. Conclusion: It can be concluded from that study that low vitamin D level may be associated with obesity and high WC, high SBP and high FPG. Thus, lower vitamin D status can be considered as increased risk of development of metabolic syndrome.

Keywords: Metabolic syndrome, vitamin D concentrations, insulin resistance.