THE ROLE OF IMMUNE RESPONSE MEDIATORS IN PATIENTS WITH ACNE

Inoyatova N. R.* and Sabirov U. Yu.

ABSTRACT

Background: Despite the fact that there are a large number of studies devoted to the study of various aspects of the problem of acne, many of its aspects remain unexplored. As you know, acne develops against the background of certain changes in the immune system. The aim of the study is to study the clinical features and levels of pro- and anti-inflammatory cytokines in patients with acne. Objective: Were examined 68 patients with acne aged 14 to 35 years. The levels of serum cytokines (IL-4, IL-6, IL-10 and IL-17A) were studied by ELISA. Result: The results of the study showed that in patients with acne, hypersecretion of the studied cytokines is noted, depending on the severity of the disease. Thus, the level of IL-4 exceeded the value of the control group by 1.9 times, IL-6 - by 2.7 times and IL-17A - by 4.3 times. Elevated levels of cytokines cause the chronic course of the disease.

Keywords: Acne, Acne immunopathogenesis, Pro- inflammatory cytokines, Interleukins.