PRONIOSOME AN ADVANCED DRUG DELIVERY SYSTEM

Mayuresh Tagad*, Harshali Mahale*, Prasad Murade, Khanderao Jadhav, Prashant Malpure and Rishikesh Bachhav

ABSTRACT

A method is presented for creating a dry product that may be hydrated right before use to make aqueous niosome dispersions that are comparable to those made by more laborious traditional procedures. These "proniosomes" increase ease in transportation, distribution, storage, and dosage while reducing issues with niosome physical stability such as aggregation, fusion, and leakage. This paper outlines the planning for niosomes generated from proniosomes are dispersed, compared to standard niosomes, and proniosome formulations are improved. Additionally, the differences between traditional and proniosome-derived niosomes are assessed in synthetic gastric or intestinal fluids, of their shape, molecular weight, particle size distribution, and drug release efficacy digestive fluid Proniosome-derived niosomes are on par with or superior than traditional niosomes in all comparisons.

Keywords: Niosomes, Proniosomes, Drug release, Lipophilic, Hydrophilic Nanoparticles, Lipid -polymer hybrid nanoparticles.