ANTIDIABETIC JOURNEY OF BENZIMIDAZOLE: A REVIEW

Ashitha Sivadas K.*, Byju K., G. Babu, Biju CR, Rinjuna Reenas and Shilpa Sathish K.

ABSTRACT

Benzimidazole core is an exceptional chemical structure that manifests vast biological and therapeutic activities like antiviral, anti-histaminic, anticancer, antiulcer, antihypertensive, antidiabetic, antifungal, and antimicrobial activity. It is a fused aromatic heterocyclic compound consists of benzene and imidazole. Aimed at the structural modifications for biological potentials, various derivatives of benzimidazole have been synthesized to increase the stability, bioavailability and promising biological profiles. This review confers about the different benzimidazole derivatives as target agents for anti-diabetic activity by inhibiting enzyme α-amylase and α- glucosidase.

Keywords: Benzimidazole, Antidiabetic, ?-amylase and ?- glucosidase.