FORMULATION AND IN VITRO CHARACTERISATION OF BUPROPION LOADED FLOATING TABLETS BY EMPLOYING EFFERVESCENT METHOD

A. Yasodha, Avinash Dundigalla and J. Sharada*

ABSTRACT

In the present research work gastro retentive floating matrix formulation of Bupropion by using various polymers were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimised. Then the formulation was developed by using different concentrations of polymers Guar gum, Xanthan gum and Chitosan as polymeric substances. The formulation blend was subjected to various preformulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations Xanthan gum as polymer were retarded the drug release for 12 hours. Where as in high concentrations the polymer was unable to produce the desired action. The formulations prepared with Xanthan gum were also retarded the drug release up to 12 hours (F5=99.83%). The optimised formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed Kors mayer peppas release kinetics mechanism of drug release.

Keywords: Bupropion, Guar gum, Xanthan gum and Chitosan, Floating Tablets.