EVALUATION OF ANALGESIC PROPERTY OF TROLOX METHYL ESTER

Lalita Sharma*, Mayank Thakur and Anurita Rajput

ABSTRACT

Objectives: The purpose of this study was to investigate the analgesic effect of Trolox Methyl Ester on rats. Materials and Methods: Using Eddy's hot plate and tail immersion procedures, the current investigation was conducted to evaluate the analgesic characteristics of Trolox Methyl Ester, in rats. Results: When compared to the control (normal saline), Trolox Methyl Ester significantly reduced the amount of writhes and significantly prolonged the reaction time in the tail clip and Eddy's hot plate method, but less so when compared to regular aspirin. Conclusion: It was concluded that Trolox Methyl Ester had significant analgesic effects in rat models of heat, chemical, and mechanical pain.

Keywords: Analgesic, Antioxidant, Eddy’s hot plate, Tail immersion, Trolox Methyl Ester.