A CASE REPORT ON ISONIAZID INDUCED CUTANEOUS REACTION

R. D. Ponmudi*, G. Ushasree, J. Thejomai, K. N. Priya Dharshini, M. Navya Sai, T. N. Vinesha Yadav and Dr. S. Subba Rao

ABSTRACT

Cutaneous reaction is a known complication of isoniazid drug therapy, although infrequent. Isoniazid is the first line drug for the treatment of tuberculosis. Tuberculosis is a common communicable public health problem. First line treatment for tuberculosis includes Isoniazid, Rifampicin, Ethambutol and Pyrazinamide. A 57 years old male patient developed cutaneous reaction by first line antitubercular therapy (ATT). In present case, the patient is a known case of Hypertension on regular medications and recently diagnosed with Pulmonary Tuberculosis and started ATT. After 3 weeks, he was presented with cutaneous reactions. Pulmonologist stopped ATT and added Antihistamines. After a week his condition was improved. After the rechallenge test with isoniazid he developed rashes again. Patient was recovered after withdrawn of the tablet Isoniazid. Cutaneous reaction in a patient on ATT can be one of the complication of tablet isoniazid. Physicians, Clinical Pharmacists & other health care providers should be aware of the adverse reactions of drugs. We need to monitor the possible reactions at regular intervals during therapy. As a health care provider, we need to prevent and minimize drug induced reactions through proper patient education & counselling.

Keywords: Pulmonary tuberculosis, Antitubercular therapy, Isoniazid, Cutaneous reaction.