REVIEW ON: ROLE OF PENETRATION ENHANCER IN TRANSDERMAL PATCH”

Phoke S. V.*, Hatkar A. D., Rawat S. S., Kundgir P. S. and Bodkhe P. M.

ABSTRACT

The human skin serves as an impediment, a thermo regulator and prevents excessive loss of water from the internal organs. Various ways of transferring the drugs have been developed by modifying the barrier properties of the skin. Today, ∼74% of drugs are taken orally and is not found to be as effective as desired. To improve such distinctiveness, transdermal drug delivery was brought to existence. This delivery system is capable of transporting the drug or macromolecules painlessly through skin into the blood circulation at fixed rate. A transversally delivered drug can only show its action when it can cross the transdermal barrier to reach the systemic circulation and for helping on doing that the penetration enhancer are the agents which increase the permeability of the skin which on return maintains the drug level in the blood. Permeation enhancers can be of a chemical type, natural type, and physical type. The present review describes the natural permeation enhancers can be which be engaged for transdermal permeation of drugs.

Keywords: macromolecules, permeation enhancers, systemic circulation.