DEVELOPMENT AND CHARACTERIZATION OF GLYCEROGELATIN SUPPOSITORIES FOR ENHANCED EFFICACY

Shubham Shende*, Bhagyashri Meshram, Heera Karemore, Prashant Gaikwad, Hemlata More, Lalchand Devhare and Ankur Srivastava

ABSTRACT

Glycerogelatin suppositories are commonly used for the treatment of various diseases such as rectal related disease, constipation, haemorrhoids, or prostate diseases. The development of this type of suppository requires the evaluation of their physical and chemical properties. This research paper aims to review the existing literature on the preparation and evaluation of glycerogelatin suppositories. The review focuses on glycerogelatin suppositories, their preparation methods, and their quality control parameters. After method of preparation we conclude that Glycerogelatin suppositories are easy method of formulation. We performed drug identification test to authenticate the Diclofenac Na by UV spectrophotometer as well as calibrate the mould to avoid variations in the weights. We evaluated various parameters such as displacement value, disintegration test, dissolution test, melting point and drug content. All the results found to be satisfactory but we need to check out the effectiveness of formulation to performed clinical study.

Keywords: Glycerogelatin suppositories, Rectal, Diclofenac Na, Displacement value etc.