A REVIEW ON POLYPHENOL USED IN CANCER

Aboli A. Netragaonkar*, Samiksha B. Deshmukh, Dr. Padmaja S. Giram and Mahesh B. Manke

ABSTRACT

Globally Cancer is a major health concern, after cardiovascular disease it is a second cause of death in noncommunicable diseases. it continues to be a extensive concern for public health systems worldwide. Recent years cancer death rate has been reduced by about 31%, by improve health status, healthier lifestyle habits. cancer occurs due to extensive DNA damage caused by ultraviolet radiations, therapeutic agents, ionizing radiations, environmental agents. Chemotherapeutic drugs are used to treat advanced stages of cancer or by following surgery. However, drug resistance developed to cancer cell it leading to failure of treatment and recurrence of the disease. Natural products like Plant-derived functional foods have a therapeutic potential and safety. Naturally derived polyphenols are beneficial in cancer treatment. it represents a structural class of mostly natural organic chemicals that consist of multiple phenol structural units. The helpful properties of polyphenols have been extensively studied for their antitumor, anti-inflammatory, and antibacterial effects, but their application extended due to their prebiotic role and their impact on the microbiota. The reported multiple anticarcinogenic properties of natually-derived polyphenols include the modulation of molecular events and signaling pathways associated with cell survival, proliferation of cancer cell, differentiation, angio- genesis, migration, hormonal activities, detoxification enzymes and immune responses. This review focused deep study of cancer, type of cancer, polyphenol as a anti-cancer agent and limitation in cancer treatment.

Keywords: cancer, polyphenols, Antineoplastic effects.