A REVIEW ON SOLUBILITY ENHANCEMENT TECHNIQUE BY MICROCRYSTALS
Venkatesh*, Theerthesh K.V., Tanuja A.J., Nagendra R. and Hanumanthachar Johsi
ABSTRACT
Poor aqueous solubility and bioavailability of drugs are the important factors affecting the absorption of drugs and consequently their therapeutic effectiveness. Reduction of particle size micro crystallization technique has new opportunities for poorly aqueous soluble drugs. The solubility problem can be solved by changing the crystal habit of a drug. The anti-solvent crystallization has been widely used for micro crystallization of drugs in the presence of polymers for increasing the dissolution rate of poorly aqueous soluble drugs. This review focusses on solubility enhancement of poorly soluble drugs by microcrystals technique.
Keywords: Microcrystals, Crystal Habit, Solubility, Enhancement, Bioavailability.
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