FORMULATION ANDINVITRO & INVIVO EVAUATION OF ITRACONAZOLE MUCCOADHESIVE SUSTAINED RELEASE TABLETS

Azmath Fathima, *Suryam Gugulothu, Manjula Jatoth, Gayathri Paturi, Sumathi Poleboina, Rajitha E., Jatoth Thabitha, Sridivya Chandragiri and Pasala Shalini

ABSTRACT

Our aim of this research work was to prepare and evaluate various evaluation parameters which are suitable for sustained release mucoadhessive tablets of Iitraconazole and to develop and characterize sustained release mucoadhessive tablets of Iitraconazole AsIitraconazole have losw solubility in aqueous phases and permeability will be high so in order to improve its solubility in HCL and water it is formulated as solid dispersion by using solvent evaporation method technique solid discussion was formulated using solvent evaporation method. In particular the buccal route appears to offer a series of advantages, such as good accessibility, robustness of the epithelium, facile removal of the dosage form in case of need, relatively low enzymatic activity, and possibility of elimination of the administered dosage from the buccal area by natural clearance mechanisms, satisfactory patient acceptance and compliance.

Keywords: Iitraconazole, mucoadhessive, solvent evaporation, robustness of the epithelium.