FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF NARATRIPATAN HCL TO IMPROVE AND SUSTAINED ITS ANTIMIGRAINE EFFECT

Bhagyashri D. Meshram*, Kalyani Dongarwar, Ashvini Parbat, Hemlata More, Mona Salwtkar,
Abhilasha Yadav

ABSTRACT

Transdermal drug delivery system (TDDS) was designed to sustain the release and improve the bioavailability of drug and patient compliance. Among the various types of transdermal patches, matrix dispersion type systems disperse the drug in the solvent along with the polymers and solvent is allowed to evaporate forming a homogeneous drug-polymer matrix. The objective of the present study was to design and formulate TDDS of Naratriptan hydrochloride and to evaluate their sustained release. Materials and Methods: In the present study, an attempt has been made to develop a matrix-type transdermal therapeutic system comprising free film method with different ratios of hydrophilic and hydrophobic polymeric combinations using solvent casting technique. Results: The physicochemical compatibility of the drug and the polymers was studied by Fourier transform infrared spectroscopy. The results obtained showed no physical-chemical incompatibility between the drug and the polymers. The patches were further subjected to various physical evaluations.

Keywords: Transdermal Drug Delivery System (TDDS), hydroxy propyl methyl cellulose (HPMC), Polyethylene glycol, Isopropyl myristate, Anti-migraine effect.