FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF LEFLUNOMIDE

Naga Jyotsna Bandi*, Nakka Ravina*, Nallatheegala Ashwini, Dr. Tulja Rani

ABSTRACT

Systems for pulsatile drug delivery are created to administer medication in accordance with the circadian behavior of illnesses. The product has a sigmoidal drug release profile, which is defined by a brief period of no release (lag time), then a quick and thorough release of the drug. By using such a method, the medicine can be supplied at the proper time, in the proper quantity, and at the proper location of action. Numerous disorders, including asthma, arthritis, cancer, diabetes, epilepsy, hypertension, ulcers, and hypercholesterolemia have been studied and their potential advantages proven. There are many capsular, osmotic, single- and multi-unit systems that can be regulated by rupturable membranes, soluble or erodible polymer coatings. These methods are helpful for diseases with chrono pharmacological behavior that call for nighttime dosage, for medications with a high first pass effect or site-specific GIT absorption, for medications with a high risk of toxicity or tolerance, and for other medications. Additionally, these methods increase patient compliance by reducing dose frequency.

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