IN-VITRO EVALUATION AND KINETIC ESTIMATION OF A PROPOSED DRUG DELIVERY SYSTEM CONTAINING KETOROLAC

Esmat Zien El-Deen*, Mamdouh Ghorab, Shadeed Gad and Heba Yassin

ABSTRACT

In the present study, solid dispersion technique was used in order to control the release of ketorolac using EudragitRS100, EudragitRL100 and ethyl cellulose in ratios of 1:1, 1:2 and 1:3 (drug to polymer) to overcome the drug related adverse effects, improve drug bioavailability in different GI tract conditions. All investigated properties showed satisfactory results. By increasing concentration of the polymers in the formula; there was increase in size distribution as well as flow properties. Drug-polymer interactions were not observed in FT-IR studies. The drug content in all of the proposed formulations was in the range of 96.45 to 102.20%. The physical state of the drug in the formulation was determined by Differential Thermal Analysis (DTA). In-vitro drug release profile of ketorolac from the proposed formulations was examined in simulated gastric fluid (SGF pH1.0) and simulated intestinal fluid (SIF pH7.4). All prepared formulations showed optimum level of controlled release and exhibited Higuchi kinetics.

Keywords: Ketorolac, Controlled release system, Solid dispersion, Oral drug delivery system.