HYPERHOMOCYSTEINEMIA IN CEREBRAL VASCULAR ACCIDENTS AND ITS ASSOCIATION WITH DEFICIENCIES IN VITAMIN B GROUPS.

Amrane Mounira, Boussouf Khaira, Attalah Salah, Chekour Mouhamed Chahine, Touabti Abdelrezek

ABSTRACT

Cerebral vascular accidents constitute a public health problem and a cause of mortality and morbidity over the world. The hyperhomocysteinemia is an independent atherothrombotic risk factor for stroke. The B12 vitamin and folic acid are important determinants in homocysteinaemia levels. Our objective is evaluated the presence and / or absence of the association of hyperhomocysteinemia as well as vitamin B12 and vitamin B9 in cerebral vascular accidents in a population of the town of Setif, Algeria. This is a transversal study that includes 60 stroke patients hospitalized at the pavilion in vascular neurology emergencies and 60 controls. The blood in these patients was taking in 24-48 hours after cerebrovascular accident diagnosed by angiography scanner. We have dosing the homocysteine, vitamin B12, B9, total cholesterol, LDL and HDL, glucose, creatinine, creatinine clearance, uric acid, CRP, ferritenemie and researched other risk factors including diabetes, hypertension, smoking, obesity and metabolic syndrome according to the criteria of ATPIII. SPSS18 statistical analysis: The average homocysteinaemia in patients is significantly elevated compared to controls (14.14 ± 5.83μmol / l vs. 9.97 ± 2.57μmol / l). Hyperhomocysteinemia is correlated to vitamin B12 deficiency; 52.63% which presents a B12 deficiency and decreased vitamin B9. Stroke (AVC) in our patient was correlated with metabolic syndrome and the hyperhomocysteinemia, hyperglycemia and deterioration of renal function. Conclusion: The high frequency of deficiencies in Group B vitamins in our patients associated to the hyperhomocysteinemia found in diabetes obliges us to take charge emergency these deficiencies in the dietary plan as well as the therapeutic level.

Keywords: Cerebral Ischemic Stroke, homocysteine, vitamin B12, vitamin B9.