A REVIEW ON PELLETS (MULTI PARTICULATE SYSTEM) AND ITS VARIOUS APPROACHES

Divakar Kumar*, Viresh K Chandur and A. R. Shabaraya

ABSTRACT

Pellets are tiny, spherical, free-flowing particles made by clumping together fine powder or granules. Pelletization techniques relate to several kinds of methods used to create pellets, (Extrusion spheronization, Hot melt extrusion, Solution or suspension layering, Powder layering, High shear pelletization, Freeze pelletization, Cryopelletization, Crystallo-co-agglomeration, Wet spherical agglomeration, Spherical crystallization etc..). Due to a number of benefits over the standard dosage form, including as dose homogeneity, dosage form flexibility, and the avoidance of dust production, pelletization has attracted a lot of interest in recent years. This review provides information on the benefits, drawbacks, ideal pellet features, medication selection criteria, and growth mechanism. It also provides a brief overview of pellet characterization, including particle size distribution, surface area, shape and sphericity, porosity, density, friability, flow property, and explanations of the disintegration and dissolution of the pellets using various applications of the techniques mentioned.

Keywords: Pellets, Extrusion spheronization, Pelletization technique, Multi-particulates.