EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

A CRITICAL REVIEW ON LD50 OF SOME MEDICINAL PLANT

Eric Omo Irinmwinuwa*, Godwin Oyate Benard, Mbah Chikodili Adolphus, Raymond Emiakpo Opute, Njoku Charles Cherechi and Juliet Orugbala Chinedu

ABSTRACT

Traditionally, humans have used herbal medicines for remedying various diseases since time immemorial. One major and overriding criterion in the selection of herbal medicines utilized in health care provision is safety. The LD50 for a particular substance is the amount that can be expected to cause death in half of animals (mice/rat). The objective of the paper was to comprehensively review the literature on the toxicity (LD50) of commonly used medicinal plant. We reviewed relevant articles and books published over the years on botany/ ethnopharmacology for their toxic effect; Vitex madiensis Oliv, Aquilaria malaccensis, Aristolochia longa, Psidium guajava, Annona squamosa, Lagerstroemia speciosa, Combretum micranthu, Ficus deltoidea, Peganum harmala, Rhizophora racemosa, Mangifera indica, Warburgia ugandensis, Alysicarpus glumaceus, Abrus precatorius, Aloe barbadensis and Tephrosia vogelii. We searched several scholarly publication. LD50 method of determining toxicity was mainly by OECD's and Lorke's, crude plant extracts were the most commonly used, Water and methanol were common solvent used, Biochemical, haematological and histopathology studies were the assay carried out to ascertain lethality (LD50) of the plant extract. The LD50 value varied with the type of cells, extracts and solvent used, making direct comparison of the plant species difficult. Most of the plant had tolerated LD50, two of plant species were toxic, namely; Abrus precatorius and Peganum harmala (2345 mg/kg and 1.8, 2.4 and 2.5mg/kg) respectively in animal models, the remaining fourteen plant species were non toxic. W. ugandensis decoctions were reported to cause adverse effect in humans by herbalist.

Keywords: Acute toxicity; Chronic toxicity; Hematological parameters; Biochemical parameters; Safety.


[Full Text Article] [Download Certificate]

Citation

  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: DECEMBER ISSUE PUBLISHED

    DECEMBER 2024 issue has been successfully launched on DECEMBER 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along witcertificate to promote resear activity of scholar.

Best Article of current issue :

Dr. Kartik Neog
Download Article : Click here