EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF STABLE DOLASETRON HCL NANOSUSPENSION FOR IMPROVED DISSOLUTION

Dasari Poojitha, *V. Jhansi Priya Marabathuni and Naidu Narapusetty

ABSTRACT

The present work was formulation development and invitro evaluation of stable Dolasetron HCL nanosuspension. Four formulations were formulated with different stablizers and surfactants. Out of four formulations, the formulation with the stabilizer and surfactant that resulted in low value of particle size and PDI were selected for further optimization. (T1- PS 287.3 and PDI 0.385). The obtained particle size, PDI and zeta potential was found to be 228.2nm, 0.376 and - 7.8mv respectively. Invitro dissolution studies revealed that formulation F5 has uplifted drug release of 92.5% and 98.9% on 40 minutes at pH 1.2 and pH 6.8 respectively. The drug release kinetics optimized nanosuspension at pH 7.4 revealed that the formulations undergone First order / anamolus / non-fickian diffusion drug release. So it is evident that formulating into nanosuspension results in improved stability, solubility and rapid drug release.

Keywords: Nanosuspension, different stablizers and surfactants, kinetics, non-fickian diffusion.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia

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