COMPARATIVE STUDIES OF DIFFERENT MARKETED BRANDS OF PARACETAMOL: AN OVERVIEW

Krishna K.R.*, Chaithanya M., Preethi B.H. and Vaishali K.

ABSTRACT

Paracetamol is an analgesic and antipyretic drug which are generally used in reducing fever and relief in pain. Paracetamol are easily available in medical shops, because it is without prescription drugs. In this time all the pharmaceutical companies produce various brands of paracetamol tablets by various technique and manufacturing process. The aim of the study is to compare and evaluate different brands of paracetamol tablets of 500mg. In this study we selected four different brands of paracetamol tablets 500mg from local markets and check their quality control parameters like weight variation, hardness, friability, disintegration and dissolution test. We found that all the test results of different brands of paracetamol tablets are obtained within acceptable limits, weight variation for all four different brands of paracetamol tablets within ±5% of their average weight and friability is not more than 1%, disintegration time for all paracetamol tablet within 15 minutes, percentage release of all brands of paracetamol tablets was found not less than 85% according IP specification limit within 30 minutes. Therefore, we concluded that all the tablets of paracetamol of different brands are safe and effective for use except the pricing.

Keywords: Paracetamol, analgesic and antipyretic, quality control.