DESIGN AND DEVELOPMENT OF VITAMIN ‘A’ STABILIZATION BY DIFFERENT TECHNIQUE

Chethan H.M.*, P.K. Kulkarni, Nagendra R., Venkatesh and Hanumanthachar Joshi

ABSTRACT

Vitamin A Palmitate (VAP) contains retinol and palmitic acid, which are essential to the body. But it is a light-sensitive molecule that undergoes degradation when exposed to UV light. The purpose of this study was to prepare a stabilised VAP powder using Spray drying and the encapsulation technique. For spray drying, an emulsion of VAP was prepared using maize starch and maltodextrin with tween 80 as an emulsifier and the resulting emulsion was spray dried. For encapsulation, VAP was mixed with MCC and sorbic acid as a preservative and the mixture was lyophilized. The stabilised powder contains 35% VAP and was produced using different concentrations of wall materials. The prepared powder was evaluated for their physical properties, drug content, in-vitro drug release and SEM study. The result showed that the obtained powder is nearly spherical in shape, with a particle size range of 1–14 μm. The drug content of different batches was found to be within an acceptable range. The drug release study showed 87.41% to 95.8% of drug release from stabilised powder at the end of 60 minutes. The formulations were kept for a 3-month stability study as per ICH guidelines and found to be stable.

Keywords: Vitamin A Palmitate, Spray drying, Encapsulation, Lyophilization, Stability studies.