FORMULATION AND EVALUATION OF LISINOPRIL AS IMMEDIATE RELEASE AND METFORMIN AS SUSTAINED RELEASE BILAYERED TABLETS

Eepuri Meshak*, A. Siva Kumar, Dr. A. Yasodha and Dr. D. Avinash

ABSTRACT

The present investigation was focused on formulation and in-vitro evaluation of a fixed dose bilayer tablet of two prominent antihypertensive agent and antidiabetic agents Lisinopril and Metformin. The tablets were designed to immediately release Lisinopril by using different percentage of sodium starch glycolate as super-disintegrant for prompt blood pressure lowering activity and sustain release metformin by varying the percentage of hydroxy propyl methylcellulose (HPMC) for prolonged activity. After evaluation of the physical and chemical parameters of the formulations according to United States Pharmacopoeia (USP) guidelines, both Lisinopril and Metformin parts were successfully compressed into bilayer tablets and post-compression parameters were evaluated. In 0.1 N HCl medium, the release of Lisinopril and Metformin it was found 98.76% 6.8 phosphate buffer medium after 8 hours.

Keywords: Bilayer tablet, Lisinopril, Metformin, FTIR Studies, Polymers, In vitro drug release studies.