A REVIEW ON NEWER APPROACHES IN PARKINSON’S DISEASE MANAGEMENT

A. Bharath Kumar*, P. Venkata Harish and C. Gopinath

ABSTRACT

Parkinson's disease is a degenerative disorder of the central nervous system mainly affecting the motor system. It is a neurodegerative disorder which is caused by lack balance between dopamine and acetylcholine levels in brain. It is characterized by chronic and progressive movement disorder. Nearly one million people in the US are living with Parkinson's disease. The cause is unknown and although there is presently no cure and there are treatment options such as medication and surgery to manage its symptoms.Patients with parkinsons disease explore bradykinesia, rigidity, tremor, postural instability. mutations involving genes that play a role in imbalacing of dopamine functions. Parkinson’s has developed at an early age individuals with mutations in genes for parkin, PINK1, LRRK2, DJ-1 and glucocerebrosidase. several newer trends are existing now to treat the conditions like stem cells therapy, Gene therapy, deep brain stimulation technique has been creating new directions for Parkinsons research. In Deep brain stimulation uses an electrode surgically implanted into part of the brain. gene therapy making cells produce a protein that they normally do not produce that might improve a particular condition. The genes that provide specific genetic instructions that cells use to produce a desired protein. It relies on transporting small pieces of genetic material into the targeted brain cells and desire improve targeted cells function.

Keywords: Bradykinesia, Rigidity, Tremor, Mutations, Genes.