A COMPREHENSIVE META-ANALYSIS OF ALDH1 IMMUNOHISTOCHEMICAL MARKER FOR BREAST CANCER STEM CELLS

Dr. Sharique Ahmad* and Pushpendra D. Pratap

ABSTRACT

Breast carcinoma, a multifaceted and heterogeneous disease, poses a formidable challenge in healthcare, demanding a profound understanding of its biology, progression, and therapeutic potential. This comprehensive meta-analysis embarks on a journey to explore the realm of identifying and targeting breast cancer stem cells (CSCs) by ALDH1 immunohistochemistry (IHC) marker. Our analysis also delves into several others markers, including the well-studied Aldehyde dehydrogenase 1 (ALDH1), CD44/CD24, Epithelial Cell Adhesion Molecule (EpCAM), and Prominin-1 (CD133). With a systematic review of the literature, our objective is to provide a nuanced and comprehensive understanding of these markers, their clinical significance, potential as prognostic indicators, and utility as therapeutic tools. This analysis underscores the need for personalized approaches to breast carcinoma management, recognizing the diverse subtypes and inherent heterogeneity within this complex disease.

Keywords: Breast carcinoma, Cancer stem cells, prognostic indicators, ALDH1.