SYNTHESIS, STRUCTURE AND BIOLOGICAL ACTIVITY OF NOVEL CURCUMIN THIOSEMICARBOZONE GOLD(III) COMPLEX: POTENTIAL ANTICANCER DRUG

Kalyani P., Subrahmanyam Naidu P. V.* and Prakash M. M. S. Kinthada*

ABSTRACT

Cancer harms the body when damaged cells divide into uncontrollably to form lumps or masses of tissue called tumors. Tumors that stay in one spot and demonstrate limited growth are generally considered to be benign. Cancerous cell manages to move throughout the body using the blood systems, destroying healthy tissue in a process called invasion. The anticancer potential of cur cumin is severely affected by its limited systemic and target tissue bioavailability and rapid metabolism. Various dietary chemo preventive agents, turmeric powder or its extract curcumin are broadly used as therapeutic preparations in Indian System of medicine. Cur cumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers. In the present research work, we provide a summarized synthesis and biological activity of curcumin/curcumin thiosemicarbozone (curTSC) derivatives of Gold(III)complex. The use of these analogs for prevention of cancer tumor progression and treatments of human malignancies.

Keywords: Curcumin, CurTSC, anticancer, therapeutic, human malignancy.