SYNTHESIS, CHARACTERIZATION AND ANTIFUNGAL ACTIVITY OF SCHIFF BASE AND ITS METAL COMPLEXES

Indu Singh* and Arun Kumar

ABSTRACT

The synthesis of a series of some novel Schiff base complexes of Cu (II), Ni (II), Co (II), Cd (II) and Zn (II) with a tetradentate Schiff base has been achieved by the reaction of 5-phenyl-1,3,4-thiadiazol-2-amine with 4-ethoxy-3-hydroxybenzaldehyde in ethanol under refluxing condition. The melting points were determined in open glass capillaries tubes. Purity of the compounds was checked by thin layer chromatography (TLC) on silica gel G plates and spots were located by using iodine chamber. All the newly synthesized metal complexes and ligand were characterized on the basis of elemental analysis, IR and 1HNMR spectral studies. All compounds were screened for their antifungal activity against A. niger C. albicans and C. krusei using fluconazole as a standard drug. It has been found that metal complexes show enhanced antifungal activity as compared to ligand.

Keywords: Co, Cu Ni, Cd and Zn complexes, Schiff base, antifungal activity, Fluconazole.